Abstract
Inhibiting metastasis is one of the biggest challenges facing cancer researchers. Metastasis is facilitated by the formation of new blood vessels (angiogenesis) as well as the lesser-known processes involved in the formation of new lymphatic vessels (lymphangiogenesis). The EDA isoform of fibronectin is expressed in some cancer cell including colorectal cell lines. Ou and colleagues investigate the role of the EDA isoform of fibronectin on the formation of lymphatic vessels. On the cover of this month’s issue of Cancer Biology & Therapy, lymphatic endothelial cells (LECs) are treated with an antibody to the EDA isoform (green). These cells show increasing disorganization of actin filaments (red), which are important for cell motility. (Nuclei are stained blue). To learn more about the effects of the EDA isoform of fibronectin on LECs, see the article by Ou and colleagues.
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