Abstract
Proper behavioral performance depends on the interaction of particular brain regions with one another. To determine the functional relations between brain areas, neural data must be obtained simultaneously from multiple brain regions and the covariance of such data assessed. If, in a given group of subjects under specific experimental conditions, two brain regions are functionally associated, their activity will be highly correlated. As indicators of functional activity, the local rate of cerebral glucose utilization (LCGU), measured in humans using positron emission tomography (PET) with fluorodeoxyglucose (FDG) and in sub-human animals using autoradiography and 2-deoxyglucose (2-DG), or regional cerebral blood flow (rCBF), measured with PET and [15-O]water, are employed.
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