Abstract
High molecular weight simian virus 40 (SV40) specific RNA molecules, whose size exceeds that of unit length virus DNA by severalfold, are present in the nuclei of productively infected monkey BS-C-1 cells. Hybridization experiments with highly purified preparations of the large viral RNA molecules show that they contain host-specific sequences covalently linked to virus-specific sequences. The results suggest that the proportion of host-specific sequences exceeds that of viral sequences in this class of viral RNA molecules and that they arise from the cotranscription of integrated viral DNA and adjacent cellular DNA during the lytic cycle of infection.
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