Covalent organic framework Schiff base network-1-based pipette tip solid phase extraction of sulfonamides from milk and honey

Abstract

In this work, a covalent organic framework Schiff base network-1 (SNW-1), was synthesized based on the Schiff base reaction between terephthalaldehyde and melamine and characterized by scanning electron microscopy, Fourier transform infrared spectroscopy, X-ray diffraction and nitrogen adsorption-desorption isotherm analyses. The prepared SNW-1 was employed as pipette tip solid phase extraction adsorbent for the extraction of sulfonamides (SAs) prior to high performance liquid chromatography analysis. The parameters affecting the extraction efficiency, including the salt concentration, sample pH, amount of adsorbent, and types and volume of eluent were investigated in detail. Good linearities were obtained between the peak area and SAs concentration ranging from 5 to 500 ng mL−1 with correlation coefficients (R2) higher than 0.9998. The limits of detection and RSDs were lower than 0.25 ng mL−1 and 1.9 %, respectively. The developed method was further applied for the determination of SAs in milk and honey samples with recoveries in the range of 85.8 % – 118.0 % and RSDs less than 9.5 %. The results demonstrate that the SNW-1 shows great potential for the enrichment of trace SAs in complex matrices.