Course of the type of patient who is candidate for radical prostatectomy over 2 decades (1989–2009)

Abstract

ObjectiveTo know the changes that there has experienced the profile of patient candidate to prostatectomía radically throughout last 2 decades in our institution. Material and methodsWe analyze retrospectively a series of 1132 patients with prostate cancer stage T1–T2, submitted to radical prostatectomy during the period 1989–2009. The series is divided into five homogeneous groups as per the number of patients and arranged chronologically. The free survival of biochemical progression (SLPB) is used as a criterion for principal forecast. ResultsIn spite of the changes in the diagnosis and treatment of the disease, from the point of view of the forecast (SLPB) we estimate two groups different from patients: the first 250 controlled ones and the rest. The point of chronological cut is placed in this series at 1999. We find significant differences in the majority of the clinical – pathological variables as PSA's level to the diagnosis (p<0.001), percentage of palpable tumors (p<0.001), clinical stage (p<0.001), Gleason in the prostate biopsy (p=0.004), groups at risk of D’Amico (p<0.001), pathological stage (p<0.001) and percentage of patients mincingly ganglionar (p<0.001). Nevertheless, there are some undetected differences of statistical significance in the Gleason of the specimen of prostatectomy (p=0.06) and in the percentage of surgical margins (p=0.6). ConclusionsThis study analyzes a patient-wide proceeding sample from the whole Spanish geography and presents some important information that reflects the evolution that has suffered the cancer of prostate located, so much regarding the diagnosis as to the forecast, in our country in the last 20 years.