Abstract
The effect of graded (5, 10, 20, and 50%) chronic ethanol administration on the intestinal mucosa has been investigated in the rat at three levels of the intestinal tract. Ethanol was administered for 8, 15, 30, and 90 days. After 8 days, there was a significant shortening of the intestinal villi. This effect was rapid, intense and more marked at the jejunal and duodenal level (−23%P < 0.001) than in the ileum (−16%P < 0.01). The general villous atrophy was followed by an increase in villous size by 15 days to beyond normal in the duodenum (+15%P < 0.01) and toward normal in the jejunum and ileum. The changes were generally maximal after 30 days (duodenum +18%P < 0.001, jejunum −23%P < 0.001, ileum −13%P < 0.001) and then tended to remain constant. All these changes indicate that ethanol exerts first a toxic effect on the intestinal epithelium followed by a secondary regenerative response which is maximal after 30 days of intoxication.
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Schedule a callMore From: Research in experimental medicine. Zeitschrift fur die gesamte experimentelle Medizin einschliesslich experimenteller Chirurgie
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