Abstract
The coupling of muscarinic agonist receptors to guanine nucleotide-binding (G) proteins was investigated in the frontal, temporal cortices and thalamus of control and Alzheimer brains by using carbachol in competition experiments with [ 3H]QNB. In the presence of GppNHp, the carbachol/[ 3H]QNB competition binding data showed a 6-fold increase in the high-affinity muscarinic agonist coefficient ( K i high) in the thalami of control brains and a significantly increased proportion of low-affinity agonist binding sites ( B max low) in the temporal cortices of control brains, while no significant effect of GppNHp was observed in Alzheimer brains. The results suggest a disturbance of the muscarinic receptor-G protein coupling in Alzheimer's disease.
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