Abstract
Abstract The Suzuki coupling reaction has been used to introduce a methyl group derived from commercially available methaneboronic acid into a vinyl triflate. This has led to a concise synthesis of all- trans -geranylgeraniol, with the key step being the Pd-catalyzed, silver-mediated methylation of 9 to give ethyl geranylgeranoate 10 . This coupling protocol has also been used to produce the novel GGPP analog 3-phenyl-3-desmethylgeranylgeranyl diphosphate ( 12 ).
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