Coupling of Fused Deposition Modeling and Inkjet Printing to Produce Drug Loaded 3D Printed Tablets.

Laura Andrade Junqueira,Dennis Douroumis,Nádia Rezende Barbosa Raposo,Marcos Antônio Fernandes Brandão,Francisco José Raposo,Atabak Ghanizadeh Tabriz,Luana Rocha Carobini,Urias Pardócimo Vaz

doi:10.3390/pharmaceutics14010159

Laura Andrade Junqueira, Dennis Douroumis + Show 6 more

Open Access

https://doi.org/10.3390/pharmaceutics14010159

Copy DOI

Abstract

In the current study, we have coupled Fused Deposition Modelling (FDM) for the fabrication of plain polyvinyl alcohol (PVA) tablets followed by dispensing of minoxidil ethanolic solutions using inkjet printing. The use of a drop-on-solid printing approach facilitates an accurate and reproducible process while it controls the deposition of the drug amounts. For the purpose of the study, the effect of the solvent was investigated and minoxidil ink solutions of ethanol 70% v/v (P70) or absolute ethanol (P100) were applied on the plain PVA tablets. Physicochemical characterization showed that solvent miscibility with the polymer substrate plays a key role and can lead to the formation of drug crystals on the surface or drug absorption in the polymer matrix. The produced minoxidil tablets showed sustained release profiles or initial bursts strongly affected by the solvent grade used for dispensing the required dose on drug loaded 3D printed tablets. This paradigm demonstrates that the coupling of FDM and inkjet printing technologies could be used for rapid development of personalized dosage forms.

Highlights

Three-dimensional printing (3DP) is a digitally controlled process used for fabrication of 3D objects, which are produced in a layer-by-layer manner
1) showed that the polyvinyl alcohol (PVA) undergo an initial decomposition at the temperature range of 90
Occurs a sharp showed that the PVA undergo an initial decomposition at the temperature range of 90–190 ◦ C, degradation at the temperature range of

Summary

Introduction

Three-dimensional printing (3DP) is a digitally controlled process used for fabrication of 3D objects, which are produced in a layer-by-layer manner. It is used in industries such as automobiles, robotics and, aerospace. Since the Food and Drugs Administration’s (FDA) approval of the Aprecia Pharmaceutical’s Spritam® (levetiracetam), the first available 3D printed tablet on the market, the interest of the pharmaceutical industry in printable oral dosage forms has grown significantly [9]. Drug release can be affected by the medicine structure, which can create new options for drug delivery [13,14,15]

Objectives

Methods

Results

Conclusion