Abstract
Functional activity, metabolism, and blood flow in the brain, although locally heterogeneous, are tightly coupled. Blood flow is adjusted to local activity in two ways: 1) short-term, dynamic coupling mediated by local vasoactive factors that ensure second-to-second regulation;and 2) long-term, static coupling apparently mediated by changes in capillary density. Recognizing these two mechanisms permits one to distinguish apparent from real uncoupling.
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