Coupling Lipid Labeling and Click Chemistry Enables Isolation of Extracellular Vesicles for Noninvasive Detection of Oncogenic Gene Alterations (Adv. Sci. 14/2022)

Abstract

Extracellular Vesicle In article number 2105853 by Renjun Pei, Shaohua Lu, Hsian-Rong Tseng, Yazhen Zhu, and co-workers, an efficient, convenient, and rapid extracellular vesicle (EV) enrichment platform called EV Click Beads is developed by combining lipid labelling and click chemistry-based capturing. EV Click Beads provides a non-invasive diagnostic solution for detection of disease status and monitoring treatment response for cancer patients, including Ewing sarcoma, the second most common type of bone cancer in children.