Coupled Nerve: A Technique to Increase the Nerve Conduction Velocity in Demyelinating Polyneuropathic Patients

Abstract

Peripheral nerve diseases in human have become a major and challenging issue in the present time period. As a result, the patients suffering from various nerve diseases such as Guillain-Barre Syndrome (GBS) and chronic inflammatory demyelinating polyneuropathy (CIDP) belongs to a group with reduced nerve conduction velocity (NCV). The reduction of NCV is caused due to the loss of myelin in the axon of the nerve. We have modelled a coupled nerve by coupling a demyelinated nerve with a myelinated nerve. We have also formulated the NCV of the modelled nerve by considering sodium ion, fast potassium ion and small amount of other ions such as calcium and chlorine ion which constitute the leakage channel in the peripheral nerves of human in order to increase the NCV of the demyelinated patients. The variation of NCV of the coupled nerve is compared with the NCV of a single, purely demyelinated nerve.