Coupled effect of particle size of the source materials and calcination temperature on the direct synthesis of hydroxyapatite.

Md Sahadat Hossain,Mashrafi Bin Mobarak,M Saiful Islam,Samina Ahmed,Monika Mahmud,Sazia Sultana

doi:10.1098/rsos.210684

Md Sahadat Hossain, Mashrafi Bin Mobarak + Show 4 more

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https://doi.org/10.1098/rsos.210684

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Abstract

We report the effect of controlled particle size (obtained by using 80, 100, 120, 140 and 200 mesh) of the source materials on the synthesis of a well-known biomaterial, hydroxyapatite (Hap). In addition to this, we have also mapped the consequence of applied temperature (700°C, 800°C and 900°C) on the crystallographic properties and phase composition of the obtained Hap. Nevertheless, although with Hap, in each case, β-tricalcium phosphate (β-TCP) was registered as the secondary phase the ANOVA test revealed that the results of the crystallographic parameters are significantly different for the applied sintering temperature 700°C and 800°C (p < 0.05), while the data obtained for calcination temperature 800°C are not significantly different from that acquired at 900°C (p > 0.05). Fourier transform infrared spectrophotometer data ensured that, irrespective of mesh size and calcination temperature, the synthesized Hap samples were of carbonated apatite with B-type substitution. Interestingly, for all cases, the % of carbonate content was below the maximum limit (8%) of the ion present in bone tissue hydroxyapatite.

Highlights

Being similar to the mineral composition of bone, hydroxyapatite (Hap) in recent times has found multi-dimensional applications royalsocietypublishing.org/journal/rsos R
We focused on using starting materials of the same particle size to facilitate a better fusion process during sintering
Such solid-state calcinations resulted in the formation of desired Hap which was ensured through several characterization techniques, as described while the entire experimental approach is depicted in figure 1

Summary

Introduction

Being similar to the mineral composition of bone, hydroxyapatite (Hap) in recent times has found multi-dimensional applications royalsocietypublishing.org/journal/rsos R. Owing to its very special properties like biocompatibility, bioactivity, osteoconductivity, nontoxicity, bone healing function etc., Hap is being used in the field of biomedical research [5,6,7,8,9,10,11,12,13]. It has found other notable applications in chromatography, biosensors, gas sensor, catalysts, fuel cells, adsorbents, etc. Regarding the importance of Hap, day by day researchers are exploring their focus on developing various synthetic routes using either chemical sources or biogenic resources/ bio-wastes [10,18,19,20]

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