Abstract
Background: On Dec 14, 2020, the United States initiated a nationwide COVID-19 vaccination campaign. Vaccination has not occurred uniformly in the United States. Only limited information describing the community-level impact of national vaccination campaigns is available. Methods: Using a negative binomial regression model we evaluated the association between county-level COVID-19 vaccine uptake and rates of COVID-19 cases and deaths in the United States from April 1, 2021 through July 31, 2021 controlling for a broad set of county-level environmental, sociodemographic, economic, and health-status-related characteristics. Findings: After adjustment for county-level characteristics, US counties with ≥70% of their adult population fully vaccinated against COVID-19 had 32% (95% CI: 19-43; P =Interpretations: Our results suggest that communities should continue to prioritize improving COVID-19 vaccination rates. US counties with ≥70% of their adult population fully vaccinated had rates of COVID-19 cases and deaths that were approximately one-third lower than counties with Funding: None to declare. Declaration of Interest: At the time of writing, all authors were employees of and hold stock and/or stock options in Pfizer Inc.
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