Abstract
Clathrin-mediated-endocytosis (CME) constitutes a ubiquitous and essential mechanism for the internalization of membrane segments or extracellular cargo in eukaryotic cells. Together with the pathway's namesake protein clathrin, dozens of other proteins contribute to the binding of specific cargo, coating the plasma membrane, inducing membrane curvature and eventual budding of vesicles. Facilitated by their characteristic honeycomb structure, clathrin-coated membranes have proven an ideal subject for correlative light and electron microscopy (CLEM) imaging. Combination of this approach with super-resolution light microscopy allowed mapping the precise locations of numerous key proteins during different stages of vesicle formation.
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