Abstract

Anomaly detection aims to detect anomaly with only normal data available for training. It attracts considerable attentions in the medical domain, as normal data is relatively easy to obtain but it is rather difficult to have abnormal data especially for some rare diseases, making training a standard classifier challenging or even impossible. Recently, generative adversarial networks (GANs) become prevalent for anomaly detection and most existing GAN-based methods detect outliers by the reconstruction error. In this paper, we propose a novel framework called adGAN for anomaly detection using GAN. Unlike existing GAN-based methods, adGAN is a discriminative model, which uses the fake data generated from GAN as an abnormal class, and then learns a boundary between normal data and simulated abnormal data. Thus it is able to output the anomaly scores directly similar as one-class SVM (OCSVM), without any reconstruction process. We explicitly design adGAN with two key elements, i.e., fake pool generation and concentration loss. The fake pool is created by incrementally collecting the fake data produced by intermediate-state GAN, which are likely surrounding the normal data distribution. The concentration loss is innovatively introduced to penalize large standard deviations of discriminator outputs for normal data, aiming to make the distribution of normal data more compact and more likely to be separated from the distribution of the potential abnormal data. The trained discriminator is finally used as an anomaly detector. We evaluated adGAN on three datasets, including ab-MNIST for synthetic anomaly detection, the ISIC'2016 for skin lesion detection, and the BraTS'2017 for brain lesion detection. The extensive experiments demonstrate that adGAN is consistently superior to its competitors on all three datasets.

Highlights

  • In this paper, we consider a specific task of anomaly detection, for which there is only normal data available for training

  • RELATED WORK Since the proposed adGAN can be considered as a special application of the generative adversarial networks (GANs), we briefly review the fundamentals of relevant GAN models and their applications for anomaly detection

  • EVALUATION The proposed adGAN is evaluated on three datasets: abMNIST, and two real medical datasets International Skin Imaging Collaboration (ISIC) and BraTS

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Summary

INTRODUCTION

We consider a specific task of anomaly detection, for which there is only normal data available for training. Ziegler et al [2] developed a Gaussian process model for pixel-level anomaly detection, which can predict the Gaussian distribution of each pixel’s intensity within the grey matter region in a healthy brain according to the age, gender, and volume of grey and white matter. Both parametric and non-parametric models are bottom-up generative approaches, and are limited to modeling distributions of normal data with low dimension. The extensive experiments demonstrate that adGAN is consistently superior to its competitors, including the well-known oneclass SVM and the recent GAN-based methods on all three datasets

RELATED WORK
15: Reset Dw with random initialization
EVALUATION
BRAIN LESION DETECTION
DISCUSSION AND CONCLUSIONS
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