Abstract
Charged polypeptides containing sulfonate groups were prepared by transesterification of poly(γ-methyl L-glutamate) with isethionic acid. The coil–helix transition of the sulfonated polypeptides was investigated in aqueous alcohols. Marked counter-ion specificity was observed for helix formation: Li+ < Na+ < Cs+ ≦ Rb+ ≦ K+; this was different to that for poly(L-glutamate) (PLG): Cs+ ≪ K+ < Li+ < Na+. Specific helix stabilization by counter-ion mixing, which has been found for the PLG system, was not observed for the sulfonated polypeptides. The counter-ion- and solvent-specific helix formation is discussed and compared with that in PLG. © 2001 Society of Chemical Industry
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