Coumarins from Peucedanum hystrix growing in Mongolia

B Taraskin,D Badamkhand,D Otgonsuren,Ee Shults,J Ganbaatar,Ld Radnaeva

doi:10.5564/mjc.v12i0.170

Abstract

It is proved to be that of genus Peucedanum hystrix serve as a source of biologically valuable natural coumarins. Nine angular furocoumarins belonging to class of 2'-substituted and 2',3'-disubstituted 2',3'-dihydrofurocoumarins have been isolated and structurally isolated. For peucenidin data of X-ray analysis is obtained.DOI: http://dx.doi.org/10.5564/mjc.v12i0.170 Mongolian Journal of Chemistry Vol.12 2011: 42-49

Highlights

Plants of Umbelliferae family are known to be a good source of naturally occurring coumarins for producing of potential medicinal preparations [1]
Separation of the hexane fraction of the root of Peucedanum hystrix Bge. 0.8 g of hexane extract was chromatographed by column chromatography. 64 mg libanorin 3, 88 mg columbianetin 6, 72 mg columbianadin 7, 72 mg peucenidin 8, 67 mg libanotin 9, 16 mg furocoumarin 10 and 20 мг furocoumarin 11 were isolated
Separation of the chloroform fraction of the roots of Peucedanum hystrix Bge. 0.8 g of chloroform extract was chromatographed by column chromatography. 16 mg angelicin 13, 48 mg oroselol 2, 24 mg coumarin 14, 24 mg columbianetin 6, 16 mg coumarin 11, 64 mg umbelliferon 5 and 60 mg vaginidiol 15 were isolated

Summary

Introduction

Plants of Umbelliferae family are known to be a good source of naturally occurring coumarins for producing of potential medicinal preparations [1]. Separation of the hexane fraction of the aerial parts of Peucedanum hystrix Bge. 0.9 g of the hexane fraction was chromatographed by column chromatography, consistently collected fractions. Separation of the hexane fraction of the root of Peucedanum hystrix Bge. 0.8 g of hexane extract was chromatographed by column chromatography. Separation of the chloroform fraction of the aerial parts of Peucedanum hystrix Bge. 0.7 g of chloroform extract was chromatographed by column chromatography. Separation of the chloroform fraction of the roots of Peucedanum hystrix Bge. 0.8 g of chloroform extract was chromatographed by column chromatography. Separation of the ether fraction of the aerial parts of Peucedanum hystrix Bge. 0.96 g of ether extract was chromatographed by column chromatography. Separation of the ether extract of the roots of Peucedanum hystrix Bge. 0.77 g of the chloroform extract was chromatographed by column chromatography. Separation of the ether extract of the roots of Peucedanum hystrix Bge. 0.77 g of the chloroform extract was chromatographed by column chromatography. 92 mg mixture of coumarins 3, 7, 10 and 11, 30 mg vaginidiol 15, 60 mg umbelliferon 5 and 69 mglibanotin 9 were isolated

Results and Discussion

Hexane

It is proved to be that plants of genus