Abstract
New coumarin based Schiff base (7MIZ) was synthesized and characterized by various spectral techniques and the true nature was established by X-ray single crystal studies. The probe (7MIZ) acted as fluorescent sensor for detection of Al3+ ion among different metal ions (chloride salts) with high selectively. There was a drastic enhancement in the emission intensity at 482 nm showed fluorescence turn ‘ON’ behavior of the probe when it interacted with Al3+ ion which may be due to CHEF (chelation enhanced fluorescence) effect that inhibited the PET (photo-induced electron transfer) mechanism. Further, Job's plot, binding constant value, LOD value, DFT studies established the interaction between probe (7MIZ) andAl3+ ion and MTT assay studies were carried out for the probe (7MIZ) and Al3+ ion in Breast cancer cell line (MDA-MB-231).
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