Abstract
5-(2,3-Dihidroxy-3-methylbuthyloxy)-6,7-methylenedioxycoumarin was isolated from the chloroform extract of the two Asteraceae species Pterocaulon alopecuroides DC. and Pterocaulon lorentzii Malme. The structure was elucidated through IR and 1 H and 13 C NMR analyses. The extracts and the isolated compound did not exhibit toxic activity, as determined through the brine shrimp lethality method, and did not interfere with the integrity of erythrocytes, as demonstrated through a hemolytic assay. The antioxidant activities were investigated through three methods. In the phosphomolybdenum test, the ethyl acetate fraction of P. alopecuroides exhibited an antioxidant activity of 137.7% compared with rutin (positive control), and the ethyl acetate fraction of P. lorentzii exhibited an antioxidant activity of 101.7% compared with vitamin C (positive control). The two ethyl acetate fraction also exhibited excellent activity through the DPPH assay: P. alopecuroides and P. lorentzii exhibited IC 50 values of 10.74 μg/ml and 7.63 μg/ml, respectively. In the TBARS bioassay, the crude extracts showed the more significant results: IA% 0.419 ± 0.0517 for P. alopecuroides and IA% 0.213 ± 0.0094 for P. lorentzii.
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