Could We Predict Adenoma Weight And Postoperative Serum Calcium Level With Preoperative Serum Biochemical Markers In Patients With Primary Hyperparathyroidism?

Abstract

Aims To determine the relationship of serum phosphate, serum calcium, and serum parathyroid hormone levels with respect to parathyroid adenoma weight and postoperative serum calcium in primary hyperparathyroidism. Materials and methods Eighty patients with single parathyroid adenoma entered the study. Preoperative serum calcium, phosphate, parathyroid hormone, alkaline phosphatase, weight of adenomas and postoperative serum calcium were recorded. Results With respect to adenoma weight, there was a significant correlation with serum calcium and parathyroid hormone (p = 0.003 and p = 0.0001, respectively).There was no correlation between postoperative serum calcium and serum alkaline phosphatase (p = 0.3), serum parathyroid hormone (p = 0.3) and adenoma weight (p = 0.1). Conclusion Adenoma weight has a positive impact on preoperative serum calcium, parathyroid hormone and alkaline phosphatase. Preoperative serum markers and adenoma weight are unreliable to predict serum calcium level postoperatively, but we can estimate the calcium decline postoperatively with preoperative serum calcium, PTH, alkaline phosphatase level and adenoma weight.