Abstract
To determine whether the preoperative platelet to lymphocyte ratio (PLR) could predict invasiveness of cervical pathologies. Patients with preinvasive and invasive diseases were reviewed retrospectively, over a nine-year period, 2005-2014. The pathological records and completed blood counts of the patients were collected and recorded in the SPSS program. Patients were divided in two groups, preinvasive and invasive. The median PLR was significantly higher in the invasive group than in the preinvasive group (p=0.03). There was a correlation between invasion of cervical cancer and white blood cell count, red cell distributing width (RDW), neutrophil-lymphocyte ratio (NLR), and PLR. This study showed that patients with uterine cervical cancer may present with leukocytosis, increased RDW, NLR and PLR. These cheap and easily available parameters, especially PLR, may provide useful information about the invasiveness of cervical lesions.
Highlights
The term preinvasive disease of the cervix (PCD) was first defined in 1947 (Pund, 1947)
There was a correlation between invasion of cervical cancer and white blood cell count, red cell distributing width (RDW), neutrophil-lymphocyte ratio (NLR), and platelet to lymphocyte ratio (PLR)
This study showed that patients with uterine cervical cancer may present with leukocytosis, increased RDW, NLR and PLR
Summary
The term preinvasive disease of the cervix (PCD) was first defined in 1947 (Pund, 1947). Despite the fact that epithelial changes give the appearance of invasive cancer on the cervix, lesions confined to the epithelium are to be noted in PCD. After PCD is defined, some studies have shown that if these lesions did not treat cervical dysplasia, it progresses to cervical cancer (Koss et al, 1963). When the preinvasive lesions could be diagnosed before the stage of the invasive cervical cancer, this early detection allows easy treatment (Richart & Sciarra, 1968). In CC, like the other cancers, the host response to malignant tumors comprises changes in the microenvironment, and systemic alterations (Tavares-Murta et al, 2010). One of the important systemic alterations is inflammation. Inflammatory markers were studied in various cancer types as indicators of invasion (Acmaz et al, 2014)
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