Abstract
Aim:To evaluate the possible superiority of outcome in patients with elevated IGF-I levels after vestibular schwannoma (VS) resection.Patients & methods:This retrospective study included 65 patients (34 male, 52.3%) with VS operated in between January 2009 and April 2014 (follow-up 3.2 ± 0.7 years). Preoperative or postoperative IGF-I levels were identified for each patient.Results:Patients were divided into two groups: Group A (small size tumor), 56 patients; and Group B (large size tumor), 9 cases. IGF-I levels in Group A (195.8 ± 32.9 ng/ml) were compared with those of Group B (242.2 ± 22.2 ng/ml) and were found to have statistically significant difference (p = 0.001).Conclusion:Increased IGF-I levels could hold a key role in nerve recovery in patients undergoing surgical resection of large VS.
Highlights
The aim of this study was to examine the possible correlation between IGF-I serum levels mainly in large vestibular schwannoma (VS) and its potential neuroprotective effect on the vestibulocochlear nerve, as this may be helpful in its management and surgical plan
Our findings suggest that an elevated level of IGF-I with value of >220 ng/ml may have a potential neuroprotective effect on vestibulocochlear nerve in patients diagnosed with large VS and may be helpful in its management and surgical plan
This study showed that there was a correlation between elevated IGF-I levels and postoperative hearing and/or facial nerve impairment in large VS cases
Summary
To evaluate the possible superiority of outcome in patients with elevated IGF-I levels after vestibular schwannoma (VS) resection. Lay abstract: The aim of this study was to examine the possible correlation between IGF-I levels in serum in large vestibular schwannomas (VS) and its potential neuroprotective effect on the vestibulocochlear nerve. The aim of this study was to examine the possible correlation between IGF-I serum levels mainly in large VS and its potential neuroprotective effect on the vestibulocochlear nerve, as this may be helpful in its management and surgical plan
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