Could body mass index be an indicator for endometrial biopsy in premenopausal women with heavy menstrual bleeding?

Abstract

To evaluate the role of body mass index (BMI) in women with premenopausal heavy menstrual bleeding (HMB) to identify patients who should undergo endometrial biopsy. This prospective cohort study included 1120 premenopausal women who presented to the Gynecology Clinic, Bakirkoy Dr. Sadi Konuk Training and Research Hospital in Istanbul, Turkey, due to HMB and who underwent endometrial sampling. The abnormal endometrial histopathological results were analyzed by separating patients into groups of all abnormal findings (hyperplasia without atypia+hyperplasia with atypia+carcinoma) and hyperplasia with atypia+carcinoma. Sensitivity and specificity of the abnormal histopathological results were calculated in both groups using BMI cut-off values as 25, 30 and 35 and age cut-offs as 40 and 45years. The rate of hyperplasia with atypia and carcinoma was sevenfold higher in women with a BMI≥30 compared to those with a BMI≤30 (95% CI 2.4-17.9). In the analyses, BMI was a stronger risk factor in women younger than 45years of age. The risk of endometrial carcinoma and atypical hyperplasia was twofold higher in patients older than 45years when compared with patients younger than 45years (95% CI 1.1-5.1). All women with a BMI≥30 and presenting premenopausal HMB should undergo endometrial biopsy regardless of age.