COULD ANTI-SYNTHETASE SYNDROME BE A GOOD PREDICTOR FACTOR FOR INTERSTITIAL LUNG DISEASE?

Sineta Cristina Firulescu,Cristina Criveanu,Adina Turcu-Stiolica,Beatrice Andreea Chisalau,Florentin Ananu Vreju,Cristina Dorina Parvanescu,Roxana Edmee Mustafa,Andreea Lili Barbulescu,Paulina Lucia Ciurea

doi:10.37897/rjr.2017.2.9

Abstract

Anti-synthetase syndrome (SAS) is an autoimmune inflammatory myopathy, whose immune profile is dominated by anti-RNA synthetase antibodies (ARS), with a specific clinical phenotype. The major diagnostic criteria of SAS include the triad of myositis, arthritis and interstitial lung disease (ILD), on the background of positive anti-ARS antibodies. ILD in SAS, has a good evolution compared to the one in PM/DM, due to protective presence of anti Jo-1 antibodies.

Highlights

Polymyositis and dermatomyositis (PM/DM) represent a group of inflammatory autoimmune myopathies (IIM), whose symp toms are including pain and weakness at the level of the proximal muscles associated with extramuscular involvement [1]
We present the case of a 68-year-old patient with familial aggregation of autoimmune diseases, who was diagnosed in 2015 with polymyositis, according to the Bohan and Peter criteria [1], and who, since 2015 until present, followed therapy with glucocorticoids
Anti-synthetase syndrome is a specific subset of autoimmune inflammatory myopathy consisting of the presence of clinical features like Raynaud’s phenomenon, arthralgia and fever, whose immunological profile is dominated by anti-RNA synthetase antibodies (ARS), having the interstitial lung disease (ILD) as a defining hallmark of the disease, in terms of morbidity and mortality [2]

Summary

CASE REPORTS

COULD ANTI-SYNTHETASE SYNDROME BE A GOOD PREDICTOR FACTOR FOR INTERSTITIAL LUNG DISEASE?. Sineta Cristina Firulescu, Paulina Lucia Ciurea, Cristina Dorina Parvanescu, Beatrice Andreea Chisalau, Andreea Lili Barbulescu, Cristina Criveanu, Adina Turcu-Stiolica, Roxana Edmee Mustafa, Florentin Ananu Vreju2 1PhD student, University of Medicine and Pharmacy of Craiova 2Department of Rheumatology, University of Medicine and Pharmacy of Craiova 3Department of Rheumatology, Emergency County Hospital Craiova 4Department of Pharmacology, University of Medicine and Pharmacy of Craiova 5Department of Pharmacoeconomics, University of Medicine and Pharmacy of Craiova 6Department of Cardiology, University of Medicine and Pharmacy of Craiova

INTRODUCTION

CASE REPORT

Findings

CONCLUSIONS