Abstract
Plant bioactive polyphenols have been used for the prevention and treatment of various diseases since ancient history. Cotton (Gossypium hirsutum L.) seeds are classified as glanded or glandless depending on the presence or absence of pigment glands, which contain polyphenolic gossypol. Diacylglycerol acyltransferases (DGATs) are integral membrane proteins that catalyze the last step of triacylglycerol biosynthesis in eukaryotes. Understanding the regulation of DGATs will provide information for therapeutic intervention for obesity and related diseases. However, little was known if DGAT gene expression was regulated by natural products. The objective of this study was to investigate the effects of cottonseed extracts and gossypol on DGAT gene expression in mouse RAW264.7 macrophages. Mouse cells were treated with different concentrations of cottonseed extracts, gossypol, and lipopolysaccharides (LPS) for various times. Quantitative polymerase chain reaction assay showed that coat extract of glanded seeds ...
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