Costimulation Blockade with CD40mAb in (Life-Supporting) Heterotopic and Orthotopic Cardiac Xenotransplantation of GalT-KO/hCD46/hTM Transgenic Pig Hearts in a Pig-to-Baboon Model

E Wolf,J.-M Abicht,A Bauer,I Lutzmann,S Buchholz,C Mcgregor,F Werner,T Mayr,C Hagl,T Pöttinger,W Hermanns,B Reichart,D Ayares,N Klymiuk,S Guethoff,J Lambris,K Reimann,P Brenner,M Mohiuddin

doi:10.1055/s-0036-1571687

Costimulation Blockade with CD40mAb in (Life-Supporting) Heterotopic and Orthotopic Cardiac Xenotransplantation of GalT-KO/hCD46/hTM Transgenic Pig Hearts in a Pig-to-Baboon Model

E Wolf, J.-M Abicht + Show 17 more

https://doi.org/10.1055/s-0036-1571687

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Journal: The Thoracic and Cardiovascular Surgeon

Publication Date: Jan 20, 2016

Affiliation: Ludwig-Maximilians-Universität München, University College London, University of Pennsylvania, University of Massachusetts Chan Medical School, Boston University, National Institutes of Health

#Costimulation Blockade #Transgenic Pig Hearts + Show 8 more

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Abstract

Aim: To verify and reproduce the excellent > 2 years long-term survival of the heterotopic, nonlife-supporting abdominal heart xenotransplantation (AHHXTx) model of Mohiuddin's group with a recombinant mouse-rhesus chimeric CD40 antibody (clone 2C10R4) this costimulation blockade was used in the life-supporting thoracic heterotopic (THHXTx) and orthotopic (OHXTx) heart transplant models.

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