Abstract
Introduction: Treatment of Multiple Myeloma with high cut off filters was started in 2007. Working hypothesis: The High Cut Off hemodialysis is a cost-efficient treatment. Objective: To demonstrate that a combination treatment of chemotherapy and High cut off dialysis improves patient survival and quality of life, while saving costs by chronic dialysis. Methodology: Up to 13 treatments with HCO filters have been applied in the University Hospital Lozano Blesa of Zaragoza to patients with acute renal failure (ARF) secondary to Multiple myeloma. Results: 13 treatments were performed on 12 patients with high cut off hemodialysis. Six patients were diagnosed with monoclonal gammopathy Kappa and 6 were diagnosed with monoclonal gammopathy Lambda, with high levels of light chains in serum over 500 mg/L (11,036 mg/L on average at the beginning). We have achieved an improvement of renal function and have allowed the patient to live without dialysis dependence in 77%. We demonstrated that the savings would be 11.782 Euros. Discussion: This paper focused on the idea that although the high cost of high cut off filters is an inconvenience, this should not impede their use because the technique has been proven more effective and cost efficient Conclusion: The treatment is cost-effective; cost savings can be estimated in more than 11,000 euros/patient.
Highlights
Treatment of Multiple Myeloma with high cut off filters was started in 2007.Working hypothesis: The High Cut Off hemodialysis is a cost-efficient treatment
We present our experience in the period between July of 2011 and February of 2015 (44 months). 13 treatments with high cut off hemodialysis were performed on 12 patients, 9 men and 3 women with a mean age of 60.8 years and range between 43 and 71 years. 6 patients were diagnosed with monoclonal gammopathy Kappa and 6 were diagnosed with monoclonal gammopathy Lambda, with high levels of serum free light chains over 500 mg/L (11.036 mg/L on average at the beginning)
A total of 151 dialysis sessions were performed, and patients stayed on a dialysis treatment with the high cut-off (HCO) filter an average of 11.53 sessions with a range between 6 and 27 sessions
Summary
Treatment of Multiple Myeloma with high cut off filters was started in 2007.Working hypothesis: The High Cut Off hemodialysis is a cost-efficient treatment. Treatment of Multiple Myeloma with high cut off filters was started in 2007. Multiple Myeloma (MM) represents 13% of hematologic cancers [1]. It is characterized by an uncontrolled proliferation of plasma cells, producing large amounts of free light chains (FLCs) which can cause obstruction of the renal tubule. The causes of renal dysfunction in patients with myeloma includes a proximal and distal tubular cell damage by alteration of the filtered light chains (FLCs), cast nephropaty, amyloidosis, deposition disease light chains or heavy [2], crioglobulinemia, interstitial infiltration by plasma cells, and rarely a proliferative glomerulonephritis or interstitial nephritis [3]. Three methods have been used to remove these free light chains in the blood: plasmapheresis, dialysis filters HCO, and recently supra HFR
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
