Abstract
ABSTRACTBackground: Streptococcus pneumoniae and non-typeable Haemophilus influenzae (NTHi) can cause invasive pneumococcal diseases (IPD), pneumonia, and acute otitis media (AOM). Both the 10-valent pneumococcal NTHi protein D conjugate vaccine (PHiD-CV) and the 13-valent pneumococcal conjugate vaccine (PCV-13) are included in the National Immunization Program for infants in Korea. This study aimed to evaluate the cost-effectiveness of the 3+1 schedule of PHiD-CV versus that of PCV-13 for National Immunization Program in Korea.Methods: A published Markov model was adapted to evaluate the cost-effectiveness of vaccinating the 2012 birth cohort with PHiD-CV vs. PCV-13 from the Korean government perspective over 10 y. Best available published data were used for epidemiology, vaccine efficacy and disutilities. Data on incidence and direct medical costs were taken from the national insurance claims database. Sensitivity analyses were conducted to explore the robustness of the results.Results: PHiD-CV was projected to prevent an additional 195,262 cases of pneumococcal diseases and NTHi-related diseases vs. PCV-13, with a substantially greater reduction in NTHi-related AOM and a comparable reduction in IPD and community-acquired pneumonia. Parity-priced PHiD-CV generated a health gain of about 844 quality-adjusted life years and a total cost-saving of approximately 4 million United States Dollars (USD) over 10 y. 93% of probabilistic simulations found PHiD-CV 3+1 to be the dominant vaccine option.Conclusion: Compared to PCV-13, PHiD-CV was projected to provide similar prevention against IPD and community-acquired pneumonia but would prevent more cases of AOM. Parity-priced PHiD-CV was anticipated to generate substantial cost-savings and health benefits vs. PCV-13 in Korea.
Highlights
Streptococcus pneumoniae (S pneumoniae) is a significant cause of a spectrum of infectious diseases worldwide, and can cause invasive pneumococcal diseases (IPD) such as meningitis and bacteremia, non-invasive lower respiratory tract infections such as pneumonia, and non-invasive upper respiratory tract infections like sinusitis and acute otitis media (AOM).[1]
There were 2 retrospective multi-center studies investigating the causative agents of invasive bacterial infections in children during 2 different study periods in Korea
This study reported that S pneumoniae accounted for 23.4% of all invasive bacterial infections
Summary
Streptococcus pneumoniae (S pneumoniae) is a significant cause of a spectrum of infectious diseases worldwide, and can cause invasive pneumococcal diseases (IPD) such as meningitis and bacteremia, non-invasive lower respiratory tract infections such as pneumonia, and non-invasive upper respiratory tract infections like sinusitis and acute otitis media (AOM).[1]. From 3 months to 5 y of age, 45.3% of the recorded cases were due to the pneumococcus pathogen.[6] Another study was conducted during the period 2006–2010, involving 25 general or university hospitals, and evaluated subjects aged less than 18 y. This study showed that IPD accounted for 23.2% of invasive bacterial infections in Korean children and that 54% of these infections manifested in children aged 3 months to less than 5 y.7. Streptococcus pneumoniae and non-typeable Haemophilus influenzae (NTHi) can cause invasive pneumococcal diseases (IPD), pneumonia, and acute otitis media (AOM). Both the 10-valent pneumococcal NTHi protein D conjugate vaccine (PHiD-CV) and the 13-valent pneumococcal conjugate vaccine (PCV-13) are included in the National Immunization Program for infants in Korea. This study aimed to evaluate the cost-effectiveness of the 3C1 schedule of PHiD-CV versus that of PCV-13 for National Immunization Program in Korea
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