Cost variation analysis of various non-steroidal anti-inflammatory drugs available in the Indian market

Abstract

Background: Non Steroidal Anti Inflammatory Drugs (NSAIDS) are used to treat a variety of conditions associated with pain and inflammation. Analysis of price variation among different brands of NSAIDS provides a guide for cost - effective prescribing and helps to reduce the financial burden on the patient and improves patient compliance. Aim: To analyze price variation of various single NSAID’s formulations available in the Indian market. Material & Methods: Price of NSAIDs manufactured by different pharmaceutical companies in India of same strength was obtained from Current Index of Medical Specialties, January-March 2022. Difference between maximum and minimum price of the same formulation, cost ratio and percentage cost variation was calculated. Results: Large price variation was seen with Celecoxib 100mg capsule (476.6%) followed by Celecoxib 200mg capsule (402.3%),Nimesulide 100mg tablet (358.33%) and Paracetamol 500mg tablet (285.06).Price variation was lowest for Mefenamic acid 250mg tablet (8%). Among the syrup formulations, it was seen that there was a price variation of 29.5% for Paracetamol 125mg/5ml, 54.15% for Ibuprofen 100mg/5ml and 37.1% for Mefenamic acid 100mg/5ml. Among the injectable NSAID’s, price variation was maximum for Diclofenac 75mg/ml (441.39%). Diclofenac 1%w/w 30gm gel showed price variation of 264.86% among the topical NSAID’s.