Abstract
Background:Sierra Leone faces among the highest maternal mortality rates worldwide. Despite this burden, the role of life–saving critical care interventions in low–resource settings remains scarcely explored. A value-based approach may be used to question whether it is sustainable and useful to start and run an obstetric intermediate critical care facility in a resource–poor referral hospital. We also aimed to investigate whether patient outcomes in terms of quality of life justified the allocated resources.Objective:To explore the value-based dimension performing a cost-utility analysis with regard to the implementation and one-year operation of the HDU. The primary endopoint was the quality-adjusted life-years (QALYs) of patients admitted to the HDU, against direct and indirect costs. Secondary endpoints included key procedures or treatments performed during the HDU stay.Methods:The study was conducted from October 2, 2017 to October 1, 2018 in the obstetric high dependency unit (HDU) of Princess Christian Maternity Hospital (PCMH) in Freetown, Sierra Leone.Findings:523 patients (median age 25 years, IQR 21–30) were admitted to HDU. The total 1 year investment and operation costs for the HDU amounted to €120,082 – resulting in €230 of extra cost per admitted patient. The overall cost per QALY gained was of €10; this value is much lower than the WHO threshold defining high cost effectiveness of an intervention, i.e. three times the current Sierra Leone annual per capita GDP of €1416.Conclusion:With an additional cost per QALY of only €10.0, the implementation and one-year running of the case studied obstetric HDU can be considered a highly cost-effective frugal innovation in limited resource contexts. The evidences provided by this study allow a precise and novel insight to policy makers and clinicians useful to prioritize interventions in critical care and thus address maternal mortality in a high burden scenario.
Highlights
Sierra Leone faces among the highest maternal mortality rates worldwide
This study aimed to evaluate from a value-based perspective whether it is sustainable, economic, and ‘useful’ to introduce an obstetric intermediate critical care setting in contexts with high morbidity and mortality coupled to limited resources to face these challenges
Study endpoints The primary endpoint was the quality-adjusted life-years (QALYs) of patients admitted to the high dependency unit (HDU) during the study period, against direct and indirect extra costs of the HDU admission
Summary
Sierra Leone faces among the highest maternal mortality rates worldwide. Despite this burden, the role of life–saving critical care interventions in low–resource settings remains scarcely explored. As international commitments in the health sector become more complex in the face of increasingly constrained aid resources, funding stakeholders increased the demand for value-for-money (VfM) assessments of global health interventions [1,2,3] This holds true for maternal and newborns health [4, 5]. With accessible and good quality clinical services, most maternal deaths may be averted—e.g., with skilled attendance to allow recognition and treatment of complications, along with a timely referral to hospitals for more complex care [6]. This hospital-based care includes various forms of obstetric intensive care support
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