Abstract
Aims: A cost–effectiveness analysis was performed to assess the efficiency of low- and iso-osmolar iodinated contrast media in patients undergoing CT in Spain. Material & methods: The primary outcome measure was the reduction of immediate and delayed adverse drug reactions (ADRs). Deterministic sensitivity analyses according to incidence rates of ADRs and clinical management of ADRs was performed. Results: Low-osmolar contrast media (vs iso-osmolar) showed cost savings of €1682.3 per ADR avoided. Additional cost savings included €799.7 and €2139.5 for each delayed and moderate-to-severe delayed ADR avoided, respectively. For low-osmolar contrast media, moderate-to-severe immediate ADRs accounted for additional costs of €1524.2 and €5781.3, respectively. Conclusion: Low-osmolar contrast media are efficient owing to lower cost and lower risk of delayed ADRs, the treatment of which is more costly.
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