Abstract
COX-2 inhibitors Lumiracoxib and Celecoxib, because these anti-inflammatory drugs increase the expression of collagens types III and IV. Methods: We evaluated in situ the presence of some granuloma components such as collagen as well as of its degradation product hydroxiprline. We also determined the local presence of relevant cytokines to granuloma formation and maintainance (TNF, TGB, IFN, GM-CSF and IL-12) and also of NO, Pb with preserved or altered morphology and the overall architecture of the granulomas. Results: The best indicators of control of PCM as expressed by successful local Pb lysis were the presence of compact granulomas, delimited by a continuous deposit of collagen type 1 arranged in concentric orientation required to contain the fungi, and the production of high concentration of cytokines IL-12 and -IFN as well as of NO. The concentration of collagen metabolite per se was not an indicator of Pb containment or dissemination. Conclusion: Based on these parameters, we can conclude that therapy with -IFN and /or Tetracycline seems promising, reducing the fungal load, increasing the production of NO and of the stimulatory cytokines -IFN and IL-12, decreasing that of the inhibitory cytokine TGBand altering the granulomas architecture towards a compact structure in order to provide Pb containment without excessive fibrosis.
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