Abstract
In this work, we sought to investigate the effects of a thiosulfinate-enriched garlic extract, co-administered with 5-fluorouracil (5-FU) or oxaliplatin chemotherapy, on the viability of colon cancer cells (Caco-2 and HT-29). We also addressed the economic feasibility of a new combined treatment of this thiosulfinate-enriched garlic extract, with oxaliplatin that could reduce the dosage and costs of a monotherapy. The thiosulfinate-enriched garlic extract not only enhanced the impact of 5-FU and oxaliplatin (500 µM) in decreasing Caco-2 and HT-29 viability, but also showed a higher effect than standard 5-FU and oxaliplatin chemotherapy as anti-cancer agents. These results provided evidences for the combination of lyophilized garlic extract and 5-FU or oxaliplatin as a novel chemotherapy regimen in colon cancer cells that may also reduce the clinical therapy costs.
Highlights
Today, the use of natural sources instead of chemical derivatives in pharmaceutical industry is a development sector within the “Biorefinery” concept worldwide [1]
As mentioned in the Material and Methods section, we used allicin content to refer the dosage of the thiosulfinate-enriched Allium sativum extract that we employed in this work
We tested the effect of the thiosulfinate-enriched Allium sativum extract on colon cancer cell viability
Summary
The use of natural sources instead of chemical derivatives in pharmaceutical industry is a development sector within the “Biorefinery” concept worldwide [1]. Most NPs show more favorable behavior compared to synthetic molecules, due to their biological properties. They can be tailored, modified or blended for new drug targets [5]. One of the most cited NP for pharmacological applications during the last years is garlic (Allium sativum) and its derivatives. The therapeutic properties of garlic have been known, researched and used for more than 5000 years by different cultures, both for the treatment and prophylaxis of a great number of pathologies [6]. Garlic and its bioactive compounds are promising as functional foods or nutraceuticals for the prevention and treatment of different diseases [8]
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