Cost-effective and green synthesized electroactive nanocomposite for high selective potentiometric determination of clomipramine hydrochloride

Abstract

Cost-effective, scalable and efficient electroactive material for ion-selective electrode was developed. Facile nanocomposite composed from montmorillonite clay layers and polyaniline nanofibers (PANI-NFs) was facilely prepared at ambient condition. The polyaniline nanofibers were polymerized on the surface of montmorillonite clay. Then the prepared nanocomposite was used as efficient electroactive modifier for developing new sensitive and selective modified carbon paste electrodes (CPE) for potentiometric determination of Clomipramine hydrochloride (CLO-HCl) in pure and pharmaceutical formulations. Effects of experimental parameters such as paste composition, response time, selectivity, pH and temperature on the potential response of CLO-HCl electrode were investigated. The paste incorporating 5 (electrode I) and 10 (electrode II) mg of developed nanocomposite (MT-PANI-NF) showed the best experimental performance, exhibiting the best Nernstian slope values of 60.30 ± 0.28 and 60.00 ± 0.22 mV decade−1 over a considerable spacious concentration range from 1.0 × 10−5 to 1.0 × 10−2 mol L−1 over pH range from 3.5 to 7.5. Additionally, a fast dynamic response time of 9 and 7 s for electrode I and II, respectively, was achieved. The proposed sensors displayed good discriminating capability toward CLO-HCl with regard to a number of interfering materials. The interaction between MT-PANI-NF nanocomposite and CLO-HCl drug at the electrode surface was studied through scanning electron microscopy (SEM) and energy dispersive X-ray analysis (EDX). The results were obtained using those electrodes were in a good agreement with those which were obtained using the official method. The method was validated according to IUPAC recommendation parameters.