Cosmetic Potential of a Liotropic Liquid Crystal Emulsion Containing Resveratrol

Laura Bonato Alves Oliveira,Nádia Raposo,Rafaela Oliveira,Camila Oliveira,Anderson Ferreira,Hudson Polonini,Marcos Brandão

doi:10.3390/cosmetics4040054

Laura Bonato Alves Oliveira, Nádia Raposo + Show 5 more

Open Access

https://doi.org/10.3390/cosmetics4040054

Copy DOI

Journal: Cosmetics	Publication Date: Dec 7, 2017
Citations: 7	License type: CC BY 4.0

Affiliation: Universidade Federal de Juiz de Fora

Abstract

Resveratrol is a natural substance that has been the target of many researchers over the years since it presents a variety of potential applications in the areas of cosmetics and medicine as a treatment for some diseases. Due to its high antioxidant capacity but low bioavailability, we evaluated the antiaging potential of resveratrol as a liotropic liquid crystal emulsion. Initially, we performed in vitro assays to quantify both the organoleptic characteristics and stability of the emulsion. Next, an in vivo trial was performed on the faces of 30 volunteers to determine the cream’s cosmetic potential and to measure porphyrins, skin barrier function, skin pigmentation, expression lines, and porosity. The emulsion maintained its characteristics during the in vitro assays and, in the in vivo trial, it had some effect only on pore size in forehead, without any significant effects on the other parameters. We had 6 dropouts throughout the study, then the final number of volunteers was 24. Most volunteers did not show any changes in skin pigmentation throughout the study. Similarly, there was not any noticeable improvement on any other parameters evaluated. However, volunteers related a high level of satisfaction with the product.

Highlights

Healthy skin is determined mainly by percutaneous absorption, plasticity, and cellular renovation [1].During the aging process, there is a lack of organization of these characteristics along with the loss of its antioxidant defense capacity, which causes an imbalance in the epithelium, resulting in an increase of free radical levels [1,2]
Free radical species causes oxidative stress in biological structures, resulting in the appearance of both physiological and biochemical changes leading to phenotypic consequences such as expression lines, flaccidity, low hydration, and skin pigmentation [2,3]
The system is inherently unstable once it is made since it is composed of a blend of two insoluble liquids united by a surfactant layer [2,3]. Another important point to be considered is that for this type of formulation to have the desired effect, the substance must be Cosmetics 2017, 4, 54; doi:10.3390/cosmetics4040054

Summary

Introduction

Healthy skin is determined mainly by percutaneous absorption, plasticity, and cellular renovation [1].During the aging process, there is a lack of organization of these characteristics along with the loss of its antioxidant defense capacity, which causes an imbalance in the epithelium, resulting in an increase of free radical levels [1,2]. Free radical species causes oxidative stress in biological structures, resulting in the appearance of both physiological and biochemical changes leading to phenotypic consequences such as expression lines, flaccidity, low hydration, and skin pigmentation [2,3]. In this regard, there is widespread interest in the development of cosmetics that could act to decrease effects of free radicals in the skin, as the human skin ages possibly because the cells accumulate free radical damage throughout time. Another important point to be considered is that for this type of formulation to have the desired effect, the substance must be Cosmetics 2017, 4, 54; doi:10.3390/cosmetics4040054 www.mdpi.com/journal/cosmetics

Objectives

Methods

Results