Abstract
Bee venom (BV) is a typical toxin secreted by stingers of honeybee workers. BV and BV therapy have long been attractive to different cultures, with extensive studies during recent decades. Nowadays, BV is applied to combat several skin diseases, such as atopic dermatitis, acne vulgaris, alopecia, vitiligo, and psoriasis. BV is used extensively in topical preparations as cosmetics and used as dressing for wound healing, as well as in facemasks. Nevertheless, the safety of BV as a therapeutic choice has always been a concern due to the immune system reaction in some people due to BV use. The documented unfavorable impact is explained by the fact that the skin reactions to BV might expand to excessive immunological responses, including anaphylaxis, that typically resolve over numerous days. This review aims to address bee venom therapeutic uses in skin cosmetics.
Highlights
Atopic dermatitis was induced by patching ovalbumin (OVA), and the OVAinduced skin thickening and inflammatory infiltration were decreased in the Bee venom (BV)-treated group, supporting the BV role as an anti-inflammatory agent [23]
BV and melittin decreased the expression of chemokines, such as CCL17 and CCL22, and pro-inflammatory cytokines, including IL-1β, IL-6, and IFN-γ, through the blockage of the nuclear factor κB (NF-κB) and STAT signaling pathways in an in vitro study using tumor necrosis factor-α (TNF-α)/IFN-γ-stimulated human keratinocytes [27]
In vitro study showed that BV induced dose-dependent melanocyte proliferation at concentrations of 10 μg/mL or higher for 7 days, resulting in an approximately twofold increase in the number of melanocytes compared to the control (Table 1) [58]
Summary
Bee venom (BV) includes a complex mixture of peptides, enzymes, lipids, and bioactive amines, and the accumulating body of data indicates its wide variety of pharmaceuti-. BV’s as topical administration can be well tolerated in acne because of its anti-inflammatory, anti-ageing [5,6], and anti-bacterial properties human skin as it has shown no risk for dermal irritation in animal studies [8]. We discuss the applications of BV as cosmetic products for skin disallergy (SAR) [10] In this context, venom immunotherapy (VIT) is the exceptional treatment eases. We discuss the applications of BV as cosmetic products for skin diseases
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