Abstract
Due to the constantly growing interest in ingredients of natural origin, this study attempts to evaluate the possibility of using extracts from three Ayurvedic plants in preparations for the care and treatment of skin diseases. Therefore, studies of antioxidant properties were carried out using DPPH and ABTS radicals, obtaining 76% and 88% of these radical scavenging, respectively. A significant decrease in the intracellular level of free radicals and an increase in the activity of the antioxidant enzyme-superoxide dismutase by almost 60% were also observed. In addition, the extracts were assessed for anti-inflammatory and anti-aging properties, obtaining over 70% inhibition of lipoxygenase activity and almost 40% of collagenase. Additionally, the cytoprotective properties of the obtained extracts on skin cells, keratinocytes and fibroblasts, were demonstrated. To assess the content of biologically active compounds, HPLC-electrospray ionization (ESI)-MS/MS multiple reaction monitoring (MRM) analyses were performed. The obtained results show that all three analyzed plants are a valuable source of biologically active substances with desired properties in the context of skin cell protection. Particularly noteworthy is the extract of Epilobium angustifolium L., for which the most promising results were obtained.
Highlights
Published: 25 January 2021Natural products are an unsurpassed source of bioactive compounds and are an important economic resource for the pharmaceutical, cosmetic and food industries
A similar tendency was observed via the analysis of the flavonoid content (TFC) for the extract obtained from Clitoria ternatea L., where the recorded value was the highest and amounted to 7.26 ± 0.12 mg QE/g DW, while the lowest was for the Centella asiatica L. extract and amounted to 0.82 ± 0.04 mg QE/g DW
The analyses of three extracts from Centella asiatica L., Clitoria ternatea L. and Epilobium angustifolium L. carried out as part of this work indicate that the analyzed plants are a valuable source of natural compounds with a broad spectrum of activity
Summary
Natural products are an unsurpassed source of bioactive compounds and are an important economic resource for the pharmaceutical, cosmetic and food industries. Centella asiatica L., commonly known as gotu kola, is a very popular plant in Ayurvedic medicine and its extracts are used to accelerate the healing of wounds, scars, psoriasis and eczema. Research of the in vitro and in vivo properties of different extracts of C. ternatea L. flowers exhibits a wide range of pharmacological aspects for the health-promoting effects This plant possesses antioxidant, antibacterial and anti-inflammatory properties [23,24]. Due to the fact that oxidative stress plays an important role in the skin condition, the study assessed the ability of extracts to neutralize free radicals (DPPH and ABTS) and the effect of the analyzed extracts on the activity of antioxidant enzyme—. The effect of the obtained extracts on skin hydration and transepidermal water loss was examined
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