Abstract
The rhizomes of Anemarrhena asphodeloide was extracted with 100% ethanol and concentrated subfractions were separated with medium pressure liquid chromatography-based activity profiling. One compound was isolated from the subfraction 10 through the repeated preparative high performance liquid chromatography (prep-HPLC). According to physico-chemical and spectroscopic data including NMR and MS, the chemical structures of the compound was determined as nyasol (1). Nyasol was exhibited potent inhibitory activity for NO (IC50: 12.5 µg/mL), tyrosinase (IC50: 12.5 µg/mL), melanin contents (IC50: 12.5 µg/mL), thymus and activation-regulated chemokine (TARC) production (IC50: 6.25 µg/mL). As a result, nyasol has an excellent inflammation- dependent anti-whitening and TARC production activity. It could be used to a large range of functional cosmetics.
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