Abstract

Isolated compounds from the leaves of Ligularia fischeri Turcz were evaluated for their cosmeceutical bioactivities. Four novel compounds, quercetin-3-O-β-d-glucoside (LF-4), quercetin-3-O-rutinoside (LF-5), ethyl-β-d-galactopyranoside (LF-7), and pterodontriol-6-O-β-d-glucopyranoside (LF-8), were isolated for the first time from this plant. Additionally, the four known compounds, 3-O-caffeoylquinic acid (LF-1), 5-O-caffeoylquinic acid (LF-2), 3, 5-di-O-caffeoylquinic acid (LF-3), and quercetin-3-O-galactoside (LF-6), were also isolated. To demonstrate the value of this plant as a cosmeceutical resource, the antioxidant activity and the inhibitory activity on tyrosinase and elastase were evaluated. The present study is the first time that the elastase inhibition of isolated compounds from L. fischeri Turcz has been investigated using the elastase inhibitory assay for anti-wrinkle effect. The ethyl acetate fraction had the highest activities in all the evaluated assays compared with the other fractions. At the compound level, LF-3 had the greatest antioxidant and elastase inhibition effect, and LF-2 showed a high level of tyrosinase inhibition. In addition, quantitative analysis of the fractions showed that the ethyl acetate fraction had the highest amount of isolated cosmeceutical bioactive compounds: LF-2, 0.9 %; LF-3, 5.3 %; LF-5, 2.8 %; and LF-6, 12.8 %.

Highlights

  • Ligularia fischeri Turcz (L. fischeri Turcz) is distributed in damp shady regions of Korea, and has long been used as a traditional oriental folk medicine for the treatment of coughs, inflammation, jaundice, scarlet fever, and rheumatoid arthritis

  • Papers relating to the bioactivity of L. fischeri Turcz have reported anti-inflammatory effects and inhibition of PTP 1B activity (Lee and Choi 2008; Deng et al 2009)

  • The purpose of this study is to demonstrate the value of L. fischeri Turcz leaves in the pharmaceutical and cosmetic industry

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Summary

Introduction

Ligularia fischeri Turcz (L. fischeri Turcz) is distributed in damp shady regions of Korea, and has long been used as a traditional oriental folk medicine for the treatment of coughs, inflammation, jaundice, scarlet fever, and rheumatoid arthritis. Nine Ligularia genuses which are L. fischeri Turcz, Ligularia schmidtii (Maxim.) Makino, Ligularia taquetii Lev. and Vaniot) Nakai, Ligularia stenocephala (Maxim.) Matsum. Koidz., Ligularia jaluensis Kom., Ligularia japonica (Thunb.) Less., Ligularia intermedia Nakai, Ligularia fischeri var. Spiciformis Nakai, and Ligularia jamesii (Hemsl.) Kom., are mainly distributed in Korea. The most studied genus is L. fischeri var. Spiciformis Nakai, a well-known wild edible Korean vegetable (Choi et al 2005; Shang et al 2010; Yoo et al 2011); the studies on L. fischeri Turcs are relatively limited. Papers relating to the bioactivity of L. fischeri Turcz have reported anti-inflammatory effects and inhibition of PTP 1B activity (Lee and Choi 2008; Deng et al 2009). The most studied genus is L. fischeri var. spiciformis Nakai, a well-known wild edible Korean vegetable (Choi et al 2005; Shang et al 2010; Yoo et al 2011); the studies on L. fischeri Turcs are relatively limited.

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