Abstract
An attempt was made to check corynebacterial infection in rats from conventional commercial sources by cortisone treatment and the results are summarized as follows :2. In cortisone-treated animals, necrotic and purulent lesions were observed frequently in the liver, kidney, heart and lung as well as the digestive tracts, whereas the organs other than the lung were involved much less frequently without cortisone-treatment.3. Organisms isolated from liver lesions of cortisone-treated rats showed similar morphological and biological characteristics as those of1. The infection was checked effectively by daily injections of 5 mg cortisone acetete intramuscularly for 10 consecutive days into 5- to 6-week-old rats weighing 59 to 117g.Corynebacterium kutscheri isolated from mice and they were agglutinated with rabbit immune serum against C. kutscheri.4. After intraperitoneal inoculation with the isolated organisms rats showed multiple necrotic and purulent lesions in the lung, liver, kidney and heart and these lesions were found to be aggravated remarkably when cortisone treatment was combined with the inoculation.
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