Abstract
ABSTRACT The metabolism of iv tracer amounts of 3H-estradiol was studied in 2 men and 2 women with total extrahepatic biliary obstruction. First-day urinary recovery of radioactivity was increased to 48% of the dose (normal 34%) and total recovery to 70% (normal 57%). “Glucosiduronates” were slightly less than normal, and “nonglucosiduronate conjugates” were increased to 39% (normal 12%). These changes probably reflect diversion of estrogen metabolites from the biliary to the urinary route of excretion. There was an abnormal pattern of estrogen metabolites within the “glucosiduronate fraction.” Estriol averaged less than half of normal. 16α-Hydroxyestrone was elevated to 3 times normal in 2 of the patients and was normal in the others. Estrone was slightly elevated. These changes indicate depression of one or both steps of the 16α-hydroxylation pathway (estrone→16α-hydroxyestrone→estriol). Two of the 4 patients showed a decrease in total 2-oxygenated metabolites (2-hydroxyestrone+2-methoxyestrone). The ra...
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