Abstract
Cortisol is produced by the periovulatory follicle from cortisone via LH/hCG-induction of type 1, 11β-hydroxysteroid dehydrogenase (11βHSD1) (cortisol synthesis) vs. type 2, 11βHSD (11βHSD2) (cortisone synthesis) (1). Follicle fluid (FF) cortisol may promote cumulus cell (CC) lipid metabolism to provide fatty acid as an energy source during oocyte meiosis (2). This study examines if FF cortisol levels correlate with CC lipid content during oocyte development, and if CCs express mRNA for glucocorticoid receptor (NR3C1), 11βHSD1/2 and the lipolytic enzymes, lipoprotein lipase [LPL] and hormone sensitive lipase [HSL].
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