Abstract
HORMONAL regulation of enzyme levels in mammalian cells has been known for more than a decade1 and the use of homogeneous populations of glucocorticoid target cells has advanced our understanding of the molecular mechanisms involved2,3. Using a specific antiserum we have now shown that cortisol induces glycerol phosphate dehydrogenase (GPDH, EC 1118) in a rat brain tumour cell line by increasing the number of GPDH molecules rather than by increasing the activity of each molecule. Also, the induction does not involve isozymes since GPDH from induced and uninduced cells is identical with respect to immunological titration, electrophoretic mobility and thermal sensitivity.
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