Abstract
Cortisol acetate has been isolated from pooled plasma from patients with rheumatoid arthritis and its identity confirmed by I-R spectroscopy. On the assumption that the difference between the total Porter-Silber chromogens and the enzymatically determined corticosteroid level represents cortisol 21-acetate, an average of 63% of the total consisted of the acetylated compound in the rheumatoid arthritis patients, but only 8% in the control group. Evidence in support of this assumption is presented and the results suggest a metabolic abnormality of clinical significance since acetylation may affect the availability at tissue sites and delay or inhibit biological activity.
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