Abstract
We investigated the effect of the perfusion of corticotropin releasing-factor (CRF) on the extracellular levels of γ-aminobutyric acid (GABA) in the hypothalamic paraventricular nucleus in the rat using a microdialysis technique. Local perfusion of CRF (3 μM, 10 μM and 30 μM) caused significant increases in extracellular GABA levels in a dose dependent manner. Increases in GABA levels in this region caused by CRF were significantly reduced by the presence of [D-Phe12, Nle21,38, α-Me-Leu37]-CRF (12-41) (D-Phe CRF12-41, 1 μM), a CRF receptor antagonist. These findings suggest that CRF activates GABAergic neurons in the rat hypothalamic paraventricular nucleus via CRF receptors, which might be related to regulation of ACTH secretion in the anterior lobe of the pituitary.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
