Abstract
This paper studies binding of one glucocorticoid hormone (corticosterone) by alveolar macrophages of rats before and after stimulation by zymosan granules. In parallel experiments Tween coverslips were incubated in medium with tritium-corticosterone to determine adsorption of the hormone on the side of the coverslip free from cells. An increase in receptor expression is one characteristic feature of activated macro= phages. This phenomenon has been linked mainly with the Fc- and C/sub 3//sup -/ -receptors of macrophages. The results described confirm that binding of corticosterone by rat pulmonary macrophages depends directly on the activity of the macrophages. The increase in sensitivity of the macrophages to anti-inflammatory hormones may be responsible for regression, in certain cases, of mononuclear infiltrates.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
