Abstract
Metabolism of corticosteroids in hypertension was further investigated. Plasma levels of “free”, “polar free”, glucuronide, and solvolyzable conjugate fractions of 17-hydroxycorticosteroids (17-OH-CS) were estimated by methods recently developed in this laboratory in 17 patients with benign uncomplicated essential hypertension and 60 normotensive control subjects. The results obtained revealed the following statistically significant differences between the 2 groups: 1) levels of 17-OH-CS glucuronides were lower in hypertensives than in normotensives; 2) levels of solvolyzable (presumably sulfate) conjugated 17-OH-CS were higher in hypertensives; 3) the ratio of glucuronides to “sulfates,” which was therefore markedly lower in hypertensives, correlated fairly well (inversely) with the blood pressure of these patients; 4) the ratio of free to solvolyzable steroids in hypertensives was decreased; 5) the ratio of polar free to free 17-OH-CS in hypertensives was increased; 6) preliminary investigation into the...
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