Abstract
Glucocorticoids are strongly immunosuppressive and are associated with reactivation of some intracellular infections. The plasmacytoid dendritic cell is a rare blood mononuclear cell detected through its production of IFN-α in response to herpes simplex virus and by surface immunophenotyping. We here report that steroid administration results in a decrease of IFN-α generation of approximately 25-fold, accompanied by reduction in circulating plasmacytoid dendritic cell numbers. Both parameters return to normal within days after steroid cessation. (J Allergy Clin Immunol 2001;108:446-8.)
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