Abstract
Publisher Summary This chapter describes those enzymes that are altered following adrenalectomy or the administration of corticosteroids. The current literature on this subject is descriptive rather than interpretive. Although it bridges the interest of endocrinologists, pharmacologists, and biochemists, few answers are to be found at present to the questions most relevant to each of these fields. In developing some perspective concerning reports of metabolic changes that underlie corticosteroid effects, it is well to recognize the preponderance of reports concerning enzymes in liver. The less-studied changes in peripheral tissues responsive to the presence of corticosteroids are of equal, if not greater, significance in understanding the primary effects of these agents. Too few simultaneous studies of metabolic changes in liver and lymphoid tissues have been carried out. Also, in most enzymatic studies, rodent tissues have been examined as a matter of convenience. Evidence for comparable changes in human tissues would be very important, yet little or no such information is available. Information cannot be extrapolated from rodents or other species to the human in the absence of substantial comparative data.
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